Sweigart Lab

Evolutionary genetics of natural populations


Biorxiv, in revision, etc.

Kerwin RE and AL Sweigart. Genome-wide misexpression associated with hybrid sterility in Mimulus (monkeyflower). biorxiv.


Mantel SJ and AL Sweigart. 2019. Divergence in drought response traits between sympatric species of Mimulus. Ecology & Evolution, early view.

Flagel LE, BK Blackman, L Fishman, PJ Monnahan, AL Sweigart, JK Kelly. 2019. GOOGA: A a platform to synthesize mapping experiments and identify genomic structural diversity. PLoS Computational Biology 15: e1006949.

Sweigart AL*, Y Brandvain*, L Fishman*. 2019. Making a murderer: on the evolutionary framing of hybrid killers. Trends in Genetics 35: 245-252. * equal contribution


Zuellig MP and AL Sweigart. 2018. A two-locus hybrid incompatibility is widespread, polymorphic, and active in natural populations of Mimulus. Evolution 72: 2394-2405.

Zuellig MP and AL Sweigart. 2018. Gene duplicates cause hybrid lethality between sympatric species of Mimulus. PLoS Genetics 14: e1007130.

Fishman L and AL Sweigart. 2018. When two rights make a wrong: evolutionary genetics of plant hybrid incompatibilities. Annual Review of Plant Biology 69: 707-731.


Kerwin RE, AL Sweigart. 2017. Mechanisms of transmission ratio distortion at hybrid sterility loci within and between Mimulus species. G3: Genes, Genomes, Genetics 7: 3719-3730.


Kenney AM, AL Sweigart. 2016. Reproductive isolation and introgression between sympatric Mimulus species. Molecular Ecology 25: 2499-2517.

Garner AG, AM Kenney, L Fishman, AL Sweigart. 2016. Genetic loci with parent of origin effects cause hybrid seed lethality between Mimulus species. New Phytologist 211: 319-331.


Ahmed-Braimah YH, AL Sweigart. 2015. A single gene causes an interspecific difference in pigmentation in Drosophila. Genetics 200: 331-342.

Sweigart AL, LE Flagel. 2015. Evidence of natural selection acting on a polymorphic hybrid incompatibility locus in Mimulus. Genetics 199: 543-554.


Brandvain Y*, AM Kenney*, L Flagel, G Coop‡, AL Sweigart‡. 2014. Speciation and introgression between Mimulus nasutus and Mimulus guttatus. PLoS Genetics 10: e1004410. * joint contribution, ‡ joint supervision

Zuellig MP, AM Kenney, AL Sweigart. 2014. Evolutionary genetics of plant adaptation: insights from new model systems. Current Opinion in Plant Biology 18: 44-50.

Fishman L, AL Sweigart, AM Kenney, S Campbell. 2014. Major QTLs control divergence in critical photoperiod for flowering between selfing and outcrossing species of monkeyflower (Mimulus). New Phytologist, 201: 1498-1507.

2012 and earlier

Sweigart AL, JH Willis. 2012. Molecular evolution and genetics of postzygotic reproductive isolation in plants. F1000 Biology Reports 4: 23.

Benedict BG, JL Modliszewski, AL Sweigart, NH Martin, JH Willis. 2012. Mimulus sookensis (Phrymaceae), a new allotetraploid species derived from Mimulus guttatus and Mimulus nasutus. Madroño 59: 29-43.

Sweigart AL. 2010. Simple Y-autosomal incompatibilities cause hybrid male sterility in reciprocal crosses between Drosophila virilis and D. americana. Genetics 184: 779-787.

Sweigart AL. 2010. The genetics of postmating, prezygotic reproductive isolation between Drosophila virilis and D. americana. Genetics 184: 401-410.

Sweigart AL. 2009. Sculpin hybrid zones: natural laboratories for the early stages of speciation. Molecular Ecology 18: 2547-2548 (Invited comment, non-peer reviewed).

Sweigart AL, NH Martin, JH Willis. 2008. Patterns of nucleotide variation and reproductive isolation between a Mimulus allotetraploid and its progenitor species. Molecular Ecology 17: 2089-2100.

Sweigart AL, AR Mason, JH Willis. 2007. Natural variation for a hybrid incompatibility between two species of Mimulus. Evolution 61: 141-151.

Sweigart AL, L Fishman, JH Willis. 2006. A simple genetic incompatibility causes hybrid male sterility in Mimulus. Genetics 172: 2465-2479.

Sweigart AL, JH Willis. 2003. Patterns of nucleotide diversity are affected by mating system and asymmetric introgression in two species of Mimulus. Evolution 57: 2490-2506.

Phippen, TM, AL Sweigart, M Moniwa, A Krumm, JR Davie, SM Parkhurst. 2000. Drosophila C-terminal binding protein functions as a context-dependent transcriptional cofactor and interferes with both Mad and Groucho transcriptional repression. Journal of Biological Chemistry 275: 37628-37637.

Sweigart A, K Karoly, A Jones, and JH Willis. 1999. The distribution of individual inbreeding coefficients and pairwise relatedness in a population of Mimulus guttatus. Heredity 8: 625-632.